It would be hard to take the ball from him. He has a decent handle and he is low. Similarly, I have no fear when a 6'5 guy is guarding me. I don't even keep my dribble low in such cases. The 6'5 guy isn't going to steal the ball unless he tries to reach, and if he reaches, I will teach.
The little guy could probably get his shot off in a regular pickup too, but he probably can't create for himself. All you have to do is stand up straight with your arms up. If he tries to drive by, just turn. Unfortunately, his stride isn't long enough to create space.
If he has different types of running floaters/scoops, he could get some buckets. However, that would still be hard if there is another defender in the lane.
Pass-First PG? Maybe.